The Broodwich is a sandwich from Hell that Master Shake discovered after Frylock convinces him to "dig for treasure" in their front yard. The earth beneath Shake opens up and he falls several feet underground into a cave, where he finds the Broodwich sitting before him. As he goes to take a bite, a mysterious voice tells him to beware. The Voice explains that the sandwich was "forged in darkness from wheat harvested in Hell's half-acre, baked by Beelzebub, slathered with mayonnaise from the evil eggs of a powerful dark chicken, beaten into sauce by the hands of a one-eyed madman, [with] cheese boiled from the rancid teat of a three-headed fanged cow [and] layered with 666 separate meats from an animal which has maggots for blood." It also has lettuce and Dijon mustard. When Shake complains about the lack of bacon, he is told that there are no swine evil enough to be sacrificed upon a bed of evil and lettuce.
Eating the sandwich sends Shake to the Broodwich Dimension where Jerry awaits him. Shake ends up eating the rest of the sandwich but doesn't disappear again. Apparently, to the Voice's great frustration, Shake picked off the sun-dried tomatoes because they were "disgusting." The Voice tells him that he passed the secret test of character and offers to let him marry a skeleton as a reward. When Shake refuses to marry her, the Voice gives him the "real" reward, free brain surgery. Shake emphatically agrees to the surgery, which leads to his lack of resistance to eating the tomatoes at the Voice's command. He goes to the Broodwich Dimension, where Jerry cuts him in half with his axe.
The Broodwich reappears in "The Last One," where the Voice tricks Romulox into eating the sun-dried tomatoes. Romulox is then sucked into the Broodwich dimension, and presumably killed.